At Tenikai General Hospital, genius doctor Takao Ameku tackles baffling medical cases that other physicians cannot solve. As he navigates through complex diagnoses, he uncovers the hidden connections between unexplained illnesses and mysterious deaths, revealing shocking truths that challenge conventional medicine. Viewers are introduced to a cast of intriguing characters, including the supportive Yū Takanashi and enigmatic Mai Kōnoike, setting the stage for thrilling medical mysteries ahead.